ADD3 Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping. Binds to calmodulin. Belongs to the aldolase class II family. Adducin subfamily. Isoform 1 is ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 10q25.1-q25.2
Cellular Component:  brush border; cell cortex; cell-cell junction; condensed nuclear chromosome; cytosol; membrane; nucleoplasm; plasma membrane
Molecular Function:  calmodulin binding; structural constituent of cytoskeleton
Biological Process:  transmembrane transport
Disease: Cerebral Palsy, Spastic Quadriplegic, 3
Reference #:  Q9UEY8 (UniProtKB)
Alt. Names/Synonyms: ADD3; ADDG; ADDL; adducin 3; adducin 3 (gamma); Adducin-like protein 70; CPSQ3; Gamma-adducin
Gene Symbols: ADD3
Molecular weight: 79,155 Da
Basal Isoelectric point: 5.92  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein