ADD3 is a heteromeric protein composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. Adducins alpha and gamma are ubiquitously expressed, while the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions of alpha and beta have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 10q25.1-q25.2
Cellular Component:  brush border; cell cortex; cell-cell junction; condensed nuclear chromosome; cytosol; membrane; nucleoplasm; plasma membrane
Molecular Function:  calmodulin binding; structural constituent of cytoskeleton
Biological Process:  transmembrane transport
Disease: Cerebral Palsy, Spastic Quadriplegic, 3
Reference #:  Q9UEY8 (UniProtKB)
Alt. Names/Synonyms: ADD3; ADDG; ADDL; adducin 3 (gamma); Adducin-like protein 70; Gamma-adducin
Gene Symbols: ADD3
Molecular weight: 79,155 Da
Basal Isoelectric point: 5.92  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein