PPPM1A Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. Belongs to the PP2C family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Motility/polarity/chemotaxis; Protein phosphatase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 14q23.1
Cellular Component:  cytosol; membrane; nucleoplasm; nucleus; plasma membrane
Molecular Function:  calmodulin-dependent protein phosphatase activity; magnesium ion binding; manganese ion binding; protein binding; protein serine/threonine phosphatase activity; R-SMAD binding
Biological Process:  cell cycle arrest; cellular response to transforming growth factor beta stimulus; dephosphorylation; N-terminal protein myristoylation; negative regulation of BMP signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of NIK/NF-kappaB signaling; negative regulation of SMAD protein complex assembly; negative regulation of transcription by RNA polymerase II; negative regulation of transforming growth factor beta receptor signaling pathway; peptidyl-threonine dephosphorylation; positive regulation of canonical Wnt signaling pathway; positive regulation of protein export from nucleus; positive regulation of transcription, DNA-templated; protein dephosphorylation
Reference #:  P35813 (UniProtKB)
Alt. Names/Synonyms: FLJ42306; MGC9201; phosphatase 2C alpha; PP2C-alpha; PP2CA; PP2Calpha; PPM1A; PPPM1A; Protein phosphatase 1A; protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform; protein phosphatase 2C alpha isoform; Protein phosphatase 2C isoform alpha; Protein phosphatase IA; protein phosphatase, Mg2+/Mn2+ dependent 1A; protein phosphatase, Mg2+/Mn2+ dependent, 1A
Gene Symbols: PPM1A
Molecular weight: 42,448 Da
Basal Isoelectric point: 5.19  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein