PKG1 an AGC kinase of the PKG family. Type I cGMP-dependent protein kinase; relaxes vascular smooth muscle and inhibits platelet aggregation. Binding of cGMP results in enzyme activation. Two splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC 2.7.11.12; Kinase, protein; PKG family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Cellular Component:  cytoplasm; cytosol
Molecular Function:  ATP binding; calcium channel regulator activity; cGMP binding; cGMP-dependent protein kinase activity
Biological Process:  negative regulation of platelet aggregation; protein phosphorylation; regulation of GTPase activity
Reference #:  P00516 (UniProtKB)
Alt. Names/Synonyms: cGK 1; cGK1; cGKI; cGMP-dependent protein kinase 1; cGMP-dependent protein kinase I; PRKG1; PRKG1B; PRKGR1A; PRKGR1B
Gene Symbols: PRKG1
Molecular weight: 76,419 Da
Basal Isoelectric point: 5.8  Predict pI for various phosphorylation states
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PKG1

Protein Structure Not Found.


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Cross-references to other databases:  STRING  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein