KCNN4 Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. Plays a role in the late stages of EGF-induced macropinocytosis. Belongs to the potassium channel KCNN family. KCa3.1/KCNN4 subfamily. Widely expressed in non-excitable tissues. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 19q13.31
Cellular Component:  plasma membrane; vesicle; voltage-gated potassium channel complex
Molecular Function:  calcium-activated potassium channel activity; potassium channel activity; protein binding; protein phosphatase binding; small conductance calcium-activated potassium channel activity
Biological Process:  calcium ion transport; cell volume homeostasis; defense response; immune system process; phospholipid translocation; positive regulation of protein secretion; positive regulation of T cell receptor signaling pathway; potassium ion transport; saliva secretion; stabilization of membrane potential
Disease: Dehydrated Hereditary Stomatocytosis 2
Reference #:  O15554 (UniProtKB)
Alt. Names/Synonyms: DHS2; hIKCa1; hKCa4; hSK4; IK; IK1; IKCA1; Intermediate conductance calcium-activated potassium channel protein 4; KCa3.1; KCA4; KCNN4; potassium calcium-activated channel subfamily N member 4; potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4; putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel; Putative Gardos channel; SK4; SKCa 4; SKCa4; small conductance calcium-activated potassium channel 4
Gene Symbols: KCNN4
Molecular weight: 47,696 Da
Basal Isoelectric point: 9.87  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene