KCNN4 Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. Plays a role in the late stages of EGF-induced macropinocytosis. Belongs to the potassium channel KCNN family. KCa3.1/KCNN4 subfamily. Widely expressed in non-excitable tissues. Note: This description may include information from UniProtKB.
Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of mouse Ortholog: 7|7 A3
Cellular Component:  apical plasma membrane; basolateral plasma membrane; cytosol; membrane; neuron projection; neuronal cell body; plasma membrane; vesicle
Molecular Function:  calcium-activated potassium channel activity; calmodulin binding; Intermediate conductance calcium-activated potassium channel activity; potassium channel activity; protein phosphatase binding; small conductance calcium-activated potassium channel activity
Biological Process:  calcium ion transport; cell volume homeostasis; establishment of localization in cell; immune system process; monoatomic anion transport; monoatomic ion transport; phospholipid translocation; positive regulation of protein secretion; positive regulation of T cell receptor signaling pathway; potassium ion export across plasma membrane; potassium ion transmembrane transport; potassium ion transport; saliva secretion; stabilization of membrane potential
Reference #:  O89109 (UniProtKB)
Alt. Names/Synonyms: IK1; IKC; IKCA1; Intermediate conductance calcium-activated potassium channel protein 4; KCa3.; KCa3.1; KCa4; Kcnn4; mIKC; mIKCa1; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4; SK4; SKCa 4; SKCa4; SKCas
Gene Symbols: Kcnn4
Molecular weight: 47,784 Da
Basal Isoelectric point: 9.82  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein