NIPP-1 Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation. Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing. Ubiquitously expressed, with highest levels in heart and skeletal muscle, followed by brain, placenta, lung, liver and pancreas. Less abundant in kidney. The concentration and ratio between isoforms is cell-type dependent. Isoform Alpha ( 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.4.-; Inhibitor; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit; Ribonuclease
Chromosomal Location of Human Ortholog: 1p35.3
Cellular Component:  cytoplasm; nuclear speck; nucleoplasm; spliceosomal complex
Molecular Function:  DNA binding; endonuclease activity; protein binding; ribonuclease E activity; RNA binding
Biological Process:  cell proliferation; mRNA processing; negative regulation of phosphoprotein phosphatase activity; RNA catabolic process; RNA phosphodiester bond hydrolysis; RNA splicing
Reference #:  Q12972 (UniProtKB)
Alt. Names/Synonyms: Activator of RNA decay; ARD-1; ARD1; NIPP-1; NIPP1; Nuclear inhibitor of protein phosphatase 1; nuclear inhibitor of protein phosphatase-1; nuclear inhibitor of protein phosphatase-1 alpha; nuclear inhibitor of protein phosphatase-1 beta; nuclear subunit of PP-1; PP1R8; PPP1R8; PRO2047; Protein phosphatase 1 regulatory inhibitor subunit 8; protein phosphatase 1 regulatory subunit 8; protein phosphatase 1, regulatory (inhibitor) subunit 8; RNase E
Gene Symbols: PPP1R8
Molecular weight: 38,479 Da
Basal Isoelectric point: 6.87  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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