GFRA1 Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. Belongs to the GDNFR family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, GPI anchor; Receptor, misc.
Chromosomal Location of rat Ortholog: 1q55
Cellular Component:  axon; external side of plasma membrane; extracellular space; Golgi apparatus; multivesicular body; neuronal cell body; plasma membrane; plasma membrane protein complex; receptor complex
Molecular Function:  integrin binding; neurotrophin receptor activity; protein binding; signaling receptor activity
Biological Process:  aging; cell migration; cell surface receptor signaling pathway; kidney development; male gonad development; nervous system development; neuron differentiation; neuron projection development; neurotrophin signaling pathway; positive regulation of peptidyl-tyrosine phosphorylation
Reference #:  Q62997 (UniProtKB)
Alt. Names/Synonyms: GDNF family receptor alpha 1; GDNF family receptor alpha-1; GDNF receptor alpha; GDNF receptor alpha-1; GDNFR-alpha; GDNFR-alpha-1; Gdnfra; GFR-alpha-1; Gfra1; glial cell line derived neurotrophic factor family receptor alpha 1; Glial cell line-derived neurotrophic factor receptor alpha; RET ligand 1; Retl1; TGF-beta-related neurotrophic factor receptor 1; Trnr1
Gene Symbols: Gfra1
Molecular weight: 51,650 Da
Basal Isoelectric point: 8.22  Predict pI for various phosphorylation states
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GFRA1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene