Tyk2 Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.2; JakA family; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group
Chromosomal Location of mouse Ortholog: 9|9 A3
Cellular Component:  cytoplasm; cytoskeleton; membrane; nucleus
Molecular Function:  ATP binding; growth hormone receptor binding; kinase activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein kinase activity; protein tyrosine kinase activity; transferase activity; type 1 angiotensin receptor binding
Biological Process:  intracellular signal transduction; phosphorylation; protein phosphorylation
Reference #:  Q9R117 (UniProtKB)
Alt. Names/Synonyms: JTK1; Non-receptor tyrosine-protein kinase TYK2; Tyk2; tyrosine kinase 2; tyrosine kinase TYK2
Gene Symbols: Tyk2
Molecular weight: 133,315 Da
Basal Isoelectric point: 6.69  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below

Tyk2

Protein Structure Not Found.


Substrate Sequence Logo
Open Substrate Page

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene