ENO1 a multifunctional enzyme and abundant cytoplasmic protein. Plays a role in glycolysis as well as various processes such as growth control, hypoxia tolerance and allergic responses. May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons. Stimulates immunoglobulin production. MBP1 binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. Belongs to the enolase family. The alpha/alpha homodimer is expressed in embryo and in most adult tissues. The alpha/beta heterodimer and the beta/beta homodimer are found in striated muscle, and the alpha/gamma heterodimer and the gamma/gamma homodimer in neurons. 2 alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 4.2.1.11; Lyase; Transcription, coactivator/corepressor
Cellular Component:  cytosol; phosphopyruvate hydratase complex
Molecular Function:  magnesium ion binding; phosphopyruvate hydratase activity
Biological Process:  gluconeogenesis; glycolytic process
Reference #:  P51913 (UniProtKB)
Alt. Names/Synonyms: 2-phospho-D-glycerate hydro-lyase; alpha enolase; Alpha-enolase; ENO-alpha; ENO1; ENOA; enolase 1, (alpha); Non-neural enolase; phosphopyruvate hydratase
Gene Symbols: ENO1
Molecular weight: 47,305 Da
Basal Isoelectric point: 6.17  Predict pI for various phosphorylation states
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ENO1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene