AA-NAT iso100 Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin. Belongs to the acetyltransferase family. AANAT subfamily. Highly expressed in pineal gland and at lower levels in the retina. Weak expression in several brain regions and in the pituitary gland. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; Amino Acid Metabolism - tryptophan; EC 2.3.1.87
Chromosomal Location of Human Ortholog: 17q25.1
Cellular Component:  cytosol; perinuclear region of cytoplasm
Molecular Function:  14-3-3 protein binding; aralkylamine N-acetyltransferase activity; arylamine N-acetyltransferase activity; protein binding
Biological Process:  cellular response to cAMP; circadian rhythm; indolalkylamine biosynthetic process; melatonin biosynthetic process; N-terminal protein amino acid acetylation; photoperiodism; response to calcium ion; response to copper ion; response to corticosterone; response to cytokine; response to insulin; response to prostaglandin E; response to zinc ion
Disease: Delayed Sleep Phase Syndrome, Susceptibility To
Reference #:  Q16613_VAR_A129T (UniProtKB)
Alt. Names/Synonyms: AA-NAT; AA-NAT iso100; AA-NAT VAR_055086 (A129T); AANAT; Aralkylamine N-acetyltransferase; arylalkylamine N-acetyltransferase; DSPS; Serotonin acetylase; Serotonin N-acetyltransferase; SNAT
Gene Symbols: AANAT
Molecular weight: 23,374 Da
Basal Isoelectric point: 7.2  Predict pI for various phosphorylation states
Select Structure to View Below

AA-NAT iso100

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein