DGKD May function as signaling molecule. Isoform 2 may be involved in cell growth and tumorigenesis. Involved in clathrin-dependent endocytosis. Belongs to the eukaryotic diacylglycerol kinase family. Isoform 2 is ubiquitously expressed also in tumor tissues. Isoform 1 is expressed in ovary, spleen and some tumor-derived cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 2q37.1
Cellular Component:  cytoplasm; cytosol; nucleus; plasma membrane
Molecular Function:  ATP binding; diacylglycerol binding; diacylglycerol kinase activity; metal ion binding; NAD+ kinase activity; protein binding; protein heterodimerization activity; protein homodimerization activity
Biological Process:  diacylglycerol metabolic process; endocytosis; epidermal growth factor receptor signaling pathway; lipid phosphorylation; multicellular organism development; platelet activation; protein homooligomerization; protein kinase C-activating G protein-coupled receptor signaling pathway; protein transport; response to organic substance; second-messenger-mediated signaling; signal transduction
Reference #:  Q16760 (UniProtKB)
Alt. Names/Synonyms: 130 kDa diacylglycerol kinase; DAG kinase delta; DGK-delta; DGKD; dgkd-2; DGKdelta; Diacylglycerol kinase delta; diacylglycerol kinase, delta 130kDa; Diglyceride kinase delta; FLJ26930; KIAA0145
Gene Symbols: DGKD
Molecular weight: 134,526 Da
Basal Isoelectric point: 7.62  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein