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DGKD
May function as signaling molecule. Isoform 2 may be involved in cell growth and tumorigenesis. Involved in clathrin-dependent endocytosis. Belongs to the eukaryotic diacylglycerol kinase family. Isoform 2 is ubiquitously expressed also in tumor tissues. Isoform 1 is expressed in ovary, spleen and some tumor-derived cells. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.1.107; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 2q37.1 |
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Cellular Component:
clathrin-coated pit; cytoplasm; cytosol; nucleus; plasma membrane
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Molecular Function:
ATP binding; ATP-dependent diacylglycerol kinase activity; diacylglycerol binding; identical protein binding; kinase binding; metal ion binding; protein binding; protein heterodimerization activity; protein homodimerization activity
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Biological Process:
diacylglycerol metabolic process; endocytosis; intracellular signal transduction; lipid phosphorylation; negative regulation of protein kinase C signaling; phosphatidic acid biosynthetic process; platelet activation; positive regulation of clathrin-dependent endocytosis; positive regulation of epidermal growth factor receptor signaling pathway; protein kinase C-activating G protein-coupled receptor signaling pathway; protein transport; signal transduction
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Reference #:
Q16760
(UniProtKB)
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Alt. Names/Synonyms: 130 kDa diacylglycerol kinase; DAG kinase delta; DGK-delta; DGKD; dgkd-2; DGKdelta; Diacylglycerol kinase delta; diacylglycerol kinase, delta 130kDa; Diglyceride kinase delta; FLJ26930; KIAA0145
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Gene Symbols: DGKD
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Molecular weight:
134,526 Da
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Basal Isoelectric point:
7.62
Predict pI for various phosphorylation states
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