CASP6 Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. Belongs to the peptidase C14A family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC 3.4.22.59; Protease
Chromosomal Location of Human Ortholog: 3|3 G3
Cellular Component:  axon; cytoplasm; cytosol; neuronal cell body; nucleoplasm; nucleus
Molecular Function:  cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type peptidase activity; endopeptidase activity; hydrolase activity; identical protein binding; peptidase activity; protein binding
Biological Process:  acute inflammatory response to non-antigenic stimulus; apoptotic process; axonal fasciculation; cellular response to staurosporine; positive regulation of apoptotic process; positive regulation of neuron apoptotic process; positive regulation of retinal cell programmed cell death; proteolysis; regulation of apoptotic process; response to cytokine; response to glucose; response to hydrogen peroxide; response to iron ion
Reference #:  O08738 (UniProtKB)
Alt. Names/Synonyms: Apoptotic protease Mch-2; CASP-6; Casp6; caspase 6; Caspase-6; Caspase-6 subunit p11; Caspase-6 subunit p18; mCAS; mCASP-6; Mch2
Gene Symbols: Casp6
Molecular weight: 31,595 Da
Basal Isoelectric point: 6.41  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  ErbB/HER Signaling  |  Inhibition of Apoptosis
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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CASP6

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene