CASP6 Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. Belongs to the peptidase C14A family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC; Protease
Chromosomal Location of human Ortholog: 4q25
Cellular Component:  cytosol; nucleoplasm
Molecular Function:  cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type peptidase activity; identical protein binding; protein binding
Biological Process:  cellular response to staurosporine; epithelial cell differentiation; execution phase of apoptosis; proteolysis; regulation of apoptotic process
Reference #:  P55212 (UniProtKB)
Alt. Names/Synonyms: Apoptotic protease Mch-2; CASP-6; CASP6; caspase 6; caspase 6, apoptosis-related cysteine peptidase; caspase 6, apoptosis-related cysteine protease; Caspase-6; Caspase-6 subunit p11; Caspase-6 subunit p18; MCH2
Gene Symbols: CASP6
Molecular weight: 33,310 Da
Basal Isoelectric point: 6.46  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  ErbB/HER Signaling  |  Inhibition of Apoptosis
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein