CASP6 Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. Belongs to the peptidase C14A family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: Apoptosis; EC 3.4.22.59; Protease

Chromosomal Location of human Ortholog: 4q25

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus; protein-containing complex

Molecular Function: cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type peptidase activity; identical protein binding; protein binding

Biological Process: activation of innate immune response; apoptotic process; cellular response to staurosporine; epithelial cell differentiation; execution phase of apoptosis; hepatocyte apoptotic process; intrinsic apoptotic signaling pathway by p53 class mediator; positive regulation of apoptotic process; positive regulation of necroptotic process; protein autoprocessing; proteolysis; pyroptosis; regulation of programmed cell death

Reference #: P55212 (UniProtKB)

Alt. Names/Synonyms: Apoptotic protease Mch-2; CASP-6; CASP6; caspase 6; caspase 6, apoptosis-related cysteine peptidase; caspase 6, apoptosis-related cysteine protease; Caspase-6; Caspase-6 subunit p11; Caspase-6 subunit p18; MCH2

Gene Symbols: CASP6

Molecular weight: 33,310 Da

Basal Isoelectric point: 6.46 Predict pI for various phosphorylation states

CST Pathways: Apoptosis Regulation | Death Receptor Signaling | ErbB/HER Signaling | Inhibition of Apoptosis

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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CASP6

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