| Tyk2 Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines. Note: This description may include information from UniProtKB. |
| Protein type: EC 2.7.10.2; JakA family; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group |
| Chromosomal Location of human Ortholog: 19p13.2 |
| Cellular Component: cytoplasm; cytoskeleton; cytosol; membrane; nucleus |
| Molecular Function: ATP binding; growth hormone receptor binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein tyrosine kinase activity; type 1 angiotensin receptor binding |
| Biological Process: cytokine-mediated signaling pathway; interleukin-12-mediated signaling pathway; interleukin-23-mediated signaling pathway; interleukin-27-mediated signaling pathway; intracellular signal transduction; peptidyl-tyrosine phosphorylation; protein phosphorylation; type I interferon signaling pathway |
| Disease: Immunodeficiency 35 |
| Reference #: P29597 (UniProtKB) |
| Alt. Names/Synonyms: IMD35; JTK1; Non-receptor tyrosine-protein kinase TYK2; TYK2; tyrosine kinase 2 |
| Gene Symbols: TYK2 |
| Molecular weight: 133,650 Da |
| Basal Isoelectric point: 6.71 Predict pI for various phosphorylation states |
| CST Pathways: Tyrosine Kinases & Substrates |
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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Tyk2 |
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