Tyk2 Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines. Note: This description may include information from UniProtKB.
Protein type: EC; JakA family; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group
Chromosomal Location of human Ortholog: 19p13.2
Cellular Component:  cytoplasm; cytoskeleton; cytosol; membrane; nucleus
Molecular Function:  ATP binding; growth hormone receptor binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein tyrosine kinase activity; type 1 angiotensin receptor binding
Biological Process:  cytokine-mediated signaling pathway; interleukin-12-mediated signaling pathway; interleukin-23-mediated signaling pathway; interleukin-27-mediated signaling pathway; intracellular signal transduction; peptidyl-tyrosine phosphorylation; protein phosphorylation; type I interferon signaling pathway
Disease: Immunodeficiency 35
Reference #:  P29597 (UniProtKB)
Alt. Names/Synonyms: IMD35; JTK1; Non-receptor tyrosine-protein kinase TYK2; TYK2; tyrosine kinase 2
Gene Symbols: TYK2
Molecular weight: 133,650 Da
Basal Isoelectric point: 6.71  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene