CACNA1S Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1S subfamily. Skeletal muscle specific. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: 
Reference #:  P07293 (UniProtKB)
Alt. Names/Synonyms: CAC1S; CACH1; CACNA1S; CACNL1A3; calcium voltage-gated channel subunit alpha1 S; CCAS; clcium channel, L type,alpha-1 polypeptide, isoform 3, skeletal muscle; voltage-dependent L-type calcium channel alpha-1S subunit; Voltage-dependent L-type calcium channel subunit alpha-1S; voltage-gated calcium channel alpha subunit Cav11; VSCC, L type, alpha 1S
Gene Symbols: CACNA1S
Molecular weight: 212,029 Da
Basal Isoelectric point: 6.16  Predict pI for various phosphorylation states
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CACNA1S
Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein