CACNA1S Pore-forming, alpha-1S subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle via their interaction with RYR1, which triggers Ca(2+) release from the sarcplasmic reticulum and ultimately results in muscle contraction. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1S subfamily. Skeletal muscle specific. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component:  cytoplasm; I band; L-type voltage-gated calcium channel complex; plasma membrane; T-tubule; voltage-gated calcium channel complex
Molecular Function:  calmodulin binding; high voltage-gated calcium channel activity; metal ion binding; protein binding; voltage-gated calcium channel activity
Biological Process:  calcium ion transmembrane transport; calcium ion transport; cardiac conduction; cellular response to caffeine; muscle contraction; regulation of ion transmembrane transport
Disease: Hypokalemic Periodic Paralysis, Type 1; Malignant Hyperthermia, Susceptibility To, 5; Thyrotoxic Periodic Paralysis, Susceptibility To, 1
Reference #:  Q13698 (UniProtKB)
Alt. Names/Synonyms: CAC1S; CACH1; CACN1; CACNA1S; CACNL1A3; calcium channel, L type, alpha 1 polypeptide, isoform 3 (skeletal muscle, hypokalemic periodic paralysis); Calcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscle; calcium channel, voltage-dependent, L type, alpha 1S subunit; Cav1.1; CCHL1A3; dihydropyridine receptor; dihydropyridine-sensitive L-type calcium channel alpha-1 subunit; HOKPP; hypoPP; MHS5; TTPP1; Voltage-dependent L-type calcium channel subunit alpha-1S; Voltage-gated calcium channel subunit alpha Cav1.1
Gene Symbols: CACNA1S
Molecular weight: 212,350 Da
Basal Isoelectric point: 6.17  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene