USP6NL Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex. Widely expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Rab; Ubiquitin-specific protease
Chromosomal Location of Human Ortholog: 2|2 A1
Cellular Component:  cytoplasmic vesicle; Golgi apparatus; plasma membrane
Molecular Function:  GTPase activator activity; Rab GTPase binding
Biological Process:  activation of GTPase activity; Golgi organization; intracellular protein transport; plasma membrane to endosome transport; positive regulation of GTPase activity; regulation of Golgi organization; retrograde transport, plasma membrane to Golgi; virion assembly
Reference #:  Q80XC3 (UniProtKB)
Alt. Names/Synonyms: AI316785; Kiaa0019; mKIAA0019; novel TBC domain containing protein; OTTMUSP00000012577; OTTMUSP00000012578; RNTRE; TRE2NL; US6NL; USP6 N-terminal like; USP6 N-terminal-like protein; Usp6nl
Gene Symbols: Usp6nl
Molecular weight: 93,574 Da
Basal Isoelectric point: 9.16  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene