|
ACC1
a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Phosphorylation by AMPK or PKA inhibits the enzymatic activity of ACC. ACC-alpha is the predominant isoform in liver, adipocyte and mammary gland. ACC-beta is the major isoform in skeletal muscle and heart. Phosphorylation regulates its activity. Note: This description may include information from UniProtKB.
|
| Protein type: Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; EC 6.4.1.2; Ligase; Lipid Metabolism - fatty acid biosynthesis |
| Chromosomal Location of Human Ortholog: 11|11 C |
|
Cellular Component:
actin cytoskeleton; cytoplasm; cytosol; fibrillar center
|
|
Molecular Function:
acetyl-CoA carboxylase activity; ATP binding; biotin binding; biotin carboxylase activity; catalytic activity; identical protein binding; kinase binding; ligase activity; metal ion binding; nucleotide binding; protein binding
|
|
Biological Process:
acetyl-CoA metabolic process; cellular response to prostaglandin E stimulus; fatty acid biosynthetic process; fatty acid metabolic process; lipid homeostasis; lipid metabolic process; metabolic process; protein homotetramerization; protein metabolic process; response to organic cyclic compound; tissue homeostasis
|
|
Reference #:
Q5SWU9
(UniProtKB)
|
|
Alt. Names/Synonyms: A530025K05Rik; Acac; Acaca; ACC-alpha; Acc1; Acetyl-CoA carboxylase 1; Acetyl-CoA carboxylase 265; acetyl-Coenzyme A carboxylase alpha; Biotin carboxylase; Gm738; OTTMUSP00000000931
|
|
Gene Symbols: Acaca
|
|
Molecular weight:
265,257 Da
|
|
Basal Isoelectric point:
5.97
Predict pI for various phosphorylation states
|
|
CST Pathways:
AMPK Signaling
|
Warburg Effect
|
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
|
