ACC1 a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Phosphorylation by AMPK or PKA inhibits the enzymatic activity of ACC. ACC-alpha is the predominant isoform in liver, adipocyte and mammary gland. ACC-beta is the major isoform in skeletal muscle and heart. Phosphorylation regulates its activity. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; EC 6.4.1.2; Ligase; Lipid Metabolism - fatty acid biosynthesis
Chromosomal Location of Human Ortholog: 11|11 C
Cellular Component:  actin cytoskeleton; cytoplasm; cytosol; fibrillar center
Molecular Function:  acetyl-CoA carboxylase activity; ATP binding; biotin binding; biotin carboxylase activity; catalytic activity; identical protein binding; kinase binding; ligase activity; metal ion binding; nucleotide binding; protein binding
Biological Process:  acetyl-CoA metabolic process; cellular response to prostaglandin E stimulus; fatty acid biosynthetic process; fatty acid metabolic process; lipid homeostasis; lipid metabolic process; metabolic process; protein homotetramerization; protein metabolic process; response to organic cyclic compound; tissue homeostasis
Reference #:  Q5SWU9 (UniProtKB)
Alt. Names/Synonyms: A530025K05Rik; Acac; Acaca; ACC-alpha; Acc1; Acetyl-CoA carboxylase 1; Acetyl-CoA carboxylase 265; acetyl-Coenzyme A carboxylase alpha; Biotin carboxylase; Gm738; OTTMUSP00000000931
Gene Symbols: Acaca
Molecular weight: 265,257 Da
Basal Isoelectric point: 5.97  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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ACC1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein