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ZNF598
E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation. Required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of 40S ribosomal protein RPS10/eS10, RPS20/uS10 and RPS3/uS3. Stalling precludes synthesis of a long poly-lysine tail and initiates the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide. Also acts as a component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation. Belongs to the ZNF598 family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: C2H2-type zinc finger protein; Ubiquitin conjugating system; Ubiquitin ligase |
| Chromosomal Location of mouse Ortholog: 17|17 A3.3 |
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Cellular Component:
cytosol; cytosolic ribosome
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Molecular Function:
metal ion binding; protein-RNA adaptor activity; ribosome binding; stalled ribosome sensor activity; transferase activity; ubiquitin protein ligase activity
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Biological Process:
negative regulation of translational initiation; protein K63-linked ubiquitination; protein monoubiquitination; protein ubiquitination; regulation of translation; rescue of stalled ribosome; ribosome-associated ubiquitin-dependent protein catabolic process
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Reference #:
Q80YR4
(UniProtKB)
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Alt. Names/Synonyms: BC023040; E3 ubiquitin-protein ligase ZNF598; Ntrap; Zfp598; Zinc finger protein 598; ZN598; Znf598
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Gene Symbols: Znf598
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Molecular weight:
99,192 Da
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Basal Isoelectric point:
8.7
Predict pI for various phosphorylation states
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