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kindlin-3
Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs). Isoform 2 may act as a repressor of NF-kappa-B and apoptosis. Belongs to the kindlin family. Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion |
| Chromosomal Location of Human Ortholog: 19|19 A |
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Cellular Component:
cell junction; cell projection; podosome
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Molecular Function:
integrin binding; protein binding
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Biological Process:
cell adhesion; integrin activation; integrin-mediated signaling pathway; leukocyte cell-cell adhesion; platelet aggregation; positive regulation of cell migration; regulation of cell-cell adhesion mediated by integrin; substrate adhesion-dependent cell spreading
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Reference #:
Q8K1B8
(UniProtKB)
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Alt. Names/Synonyms: C79673; Fermitin family homolog 3; fermitin family homolog 3 (Drosophila); Fermt3; Kind3; Kindlin-3; Kindlin3; MGC36836; MGC38286; Unc-112-related protein 2; Urp2
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Gene Symbols: Fermt3
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Molecular weight:
75,635 Da
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Basal Isoelectric point:
6.6
Predict pI for various phosphorylation states
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Protein-Specific Antibodies or siRNAs from Cell Signaling Technology®
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