RAI1 May function as a transcriptional regulator. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. Defects in RAI1 are a cause of Smith-Magenis syndrome (SMS). SMS is characterized by congenital mental retardation associated with development and growth delays. Affected persons have characteristic behavioral abnormalities, including self-injurious behaviors and sleep disturbance, and distinct craniofacial and skeletal anomalies. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 11|11 B1.3-B2
Cellular Component:  cytoplasm; mitochondrion; nucleoplasm; nucleus
Molecular Function:  DNA-binding transcription factor activity; enhancer binding; metal ion binding; transcription regulatory region DNA binding
Biological Process:  circadian regulation of gene expression; negative regulation of multicellular organism growth; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; rhythmic process; skeletal system development
Reference #:  Q61818 (UniProtKB)
Alt. Names/Synonyms: Gt1; Kiaa1820; OTTMUSP00000005990; Rai1; retinoic acid induced 1; Retinoic acid-induced protein 1
Gene Symbols: Rai1
Molecular weight: 201,571 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene