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MST3
Serine/threonine-protein kinase that acts on both serine and threonine residues and promotes apoptosis in response to stress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2 (MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) during oxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nuclear translocation of AIFM1 and ENDOG and the DNase activity associated with ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates its kinase activity. In association with STK26 negatively regulates Golgi reorientation in polarized cell migration upon RHO activation. Regulates also cellular migration with alteration of PTPN12 activity and PXN phosphorylation: phosphorylates PTPN12 and inhibits its activity and may regulate PXN phosphorylation through PTPN12. May act as a key regulator of axon regeneration in the optic nerve and radial nerve. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family; YSK subfamily |
| Chromosomal Location of mouse Ortholog: 14 E5|14 64.95 cM |
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Cellular Component:
cytoplasm; cytosol; Golgi apparatus; Golgi membrane; membrane; nucleolus; nucleus
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Molecular Function:
ATP binding; kinase activity; metal ion binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
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Biological Process:
apoptotic process; cellular response to starvation; execution phase of apoptosis; intrinsic apoptotic signaling pathway in response to oxidative stress; negative regulation of cell migration; phosphorylation; positive regulation of axon regeneration; protein autophosphorylation; protein phosphorylation; regulation of axon regeneration; response to hydrogen peroxide
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Reference #:
Q99KH8
(UniProtKB)
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Alt. Names/Synonyms: 1810013H02Rik; C76483; Mammalian STE20-like protein kinase 3; Mammalian STE20-like protein kinase 3 C-terminal; Mammalian STE20-like protein kinase 3 N-terminal; mammalian sterile twenty 3 kinase; MGC6330; MST-3; Mst3; MST3/C; MST3/N; serine/threonine kinase 24; serine/threonine kinase 24 (STE20 homolog, yeast); Serine/threonine-protein kinase 24; Serine/threonine-protein kinase 24 12 kDa subunit; Serine/threonine-protein kinase 24 35 kDa subunit; STE2; STE20; STE20-like kinase MST3; Stk24; Stk3
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Gene Symbols: Stk24
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Molecular weight:
47,954 Da
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Basal Isoelectric point:
5.29
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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