DIXDC1 iso2
Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2. Belongs to the DIXDC1 family. Ubiquitously expressed with higher expression in cardiac and skeletal muscles. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Cell adhesion; Cell development/differentiation |
Chromosomal Location of human Ortholog: 11q23.1 |
Cellular Component:
cytoskeleton; cytosol; focal adhesion
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Molecular Function:
actin binding; gamma-tubulin binding; protein binding; protein domain specific binding
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Biological Process:
canonical Wnt signaling pathway; cerebral cortex radially oriented cell migration; forebrain ventricular zone progenitor cell division; negative regulation of neuron differentiation; positive regulation of Wnt signaling pathway; regulation of actin cytoskeleton organization; regulation of microtubule cytoskeleton organization
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Reference #:
Q155Q3-2
(UniProtKB)
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Alt. Names/Synonyms: CCD1; Coiled-coil protein DIX1; Coiled-coil-DIX1; DIX domain containing 1; DIX domain-containing protein 1; DIXC1; DIXDC1; DIXDC1 iso2; Dixin; KIAA1735
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Gene Symbols: DIXDC1
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Molecular weight:
53,942 Da
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Basal Isoelectric point:
5.36
Predict pI for various phosphorylation states
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