ASIC1 Isoform 2 and isoform 3 function as proton-gated sodium channels; they are activated by a drop of the extracellular pH and then become rapidly desensitized. The channel generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Isoform 2 can also transport potassium, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Isoform 3 can also transport calcium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear. Isoform 1 does not display proton-gated cation channel activity. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC1 subfamily. Expressed in most or all neurons. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of Human Ortholog: 15|15 F1
Cellular Component:  cell surface; dendritic shaft; dendritic spine; Golgi apparatus; integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; synapse
Molecular Function:  acid-sensing ion channel activity; cation channel activity; ion channel activity; ion gated channel activity; ligand-gated sodium channel activity; monovalent inorganic cation transmembrane transporter activity; protein binding; sodium channel activity
Biological Process:  associative learning; behavioral fear response; calcium ion transmembrane transport; calcium ion transport; cation transport; cellular response to pH; ion transmembrane transport; ion transport; memory; monovalent inorganic cation transport; negative regulation of neurotransmitter secretion; regulation of membrane potential; response to acidic pH; response to amphetamine; sensory perception of sour taste; sodium ion transmembrane transport; sodium ion transport
Reference #:  Q6NXK8 (UniProtKB)
Alt. Names/Synonyms: Acc; Accn2; acid sensing ion channel; acid-sensing (proton-gated) ion channel 1; Acid-sensing ion channel; Acid-sensing ion channel 1; AI843610; Amiloride-sensitive cation channel 2, neuronal; Asic; Asic1; ASIC1a; B530003N02Rik; BNa; BNaC2; Brain sodium channel 2; degenerin 2
Gene Symbols: Accn2
Molecular weight: 59,668 Da
Basal Isoelectric point: 5.38  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene