CRYA1 Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Belongs to the small heat shock protein (HSP20) family. Expressed in eye lens. Note: This description may include information from UniProtKB.
Protein type: Chaperone; Heat shock protein
Chromosomal Location of Human Ortholog: 20p12
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function:  identical protein binding; metal ion binding; protein binding; structural constituent of eye lens; unfolded protein binding
Biological Process:  actin filament organization; apoptotic process; apoptotic process involved in morphogenesis; camera-type eye development; embryonic camera-type eye morphogenesis; lens development in camera-type eye; lens fiber cell morphogenesis; lens morphogenesis in camera-type eye; microtubule-based process; mitochondrion organization; multicellular organism aging; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of gene expression; negative regulation of intracellular transport; positive regulation of cell growth; positive regulation of protein phosphorylation; protein folding; protein homooligomerization; protein stabilization; response to drug; response to glucocorticoid; response to hydrogen peroxide; response to hypoxia; response to lead ion; response to UV-A; tubulin complex assembly; visual perception
Reference #:  P24623-2 (UniProtKB)
Alt. Names/Synonyms: Acry-1; Alpha-crystallin A chain; Crya1; Cryaa; Crystallin, alpha A; Crystallin, alpha polypeptide A
Gene Symbols: Cryaa
Molecular weight: 19,792 Da
Basal Isoelectric point: 5.78  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein