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CRYA1
Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Belongs to the small heat shock protein (HSP20) family. Expressed in eye lens. Note: This description may include information from UniProtKB.
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| Protein type: Chaperone; Heat shock protein |
| Chromosomal Location of rat Ortholog: 20p12 |
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Cellular Component:
cytoplasm; cytosol; nucleoplasm; nucleus; protein-containing complex
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Molecular Function:
identical protein binding; metal ion binding; protein binding; structural constituent of eye lens; structural molecule activity; unfolded protein binding
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Biological Process:
actin filament organization; apoptotic process; apoptotic process involved in morphogenesis; camera-type eye development; embryonic camera-type eye morphogenesis; lens development in camera-type eye; lens fiber cell morphogenesis; lens morphogenesis in camera-type eye; microtubule-based process; mitochondrion organization; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of gene expression; negative regulation of intracellular transport; positive regulation of cell growth; positive regulation of protein phosphorylation; protein folding; protein refolding; protein stabilization; response to glucocorticoid; response to heat; response to hydrogen peroxide; response to hypoxia; response to lead ion; response to UV-A; response to xenobiotic stimulus; tubulin complex assembly; visual perception
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Reference #:
P24623
(UniProtKB)
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Alt. Names/Synonyms: Acry-1; Alpha-crystallin A chain; Crya1; Cryaa; Crystallin, alpha A; Crystallin, alpha polypeptide A
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Gene Symbols: Cryaa
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Molecular weight:
22,447 Da
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Basal Isoelectric point:
6.35
Predict pI for various phosphorylation states
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