CRYA1 Contributes to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. Belongs to the small heat shock protein (HSP20) family. Expressed in eye lens. Note: This description may include information from UniProtKB.
Protein type: Chaperone; Heat shock protein
Chromosomal Location of human Ortholog: 21q22.3
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function:  identical protein binding; metal ion binding; protein binding; structural constituent of eye lens; unfolded protein binding
Biological Process:  negative regulation of apoptotic process; negative regulation of intracellular transport; protein homooligomerization; protein stabilization; response to stimulus; visual perception
Disease: Cataract 9, Multiple Types
Reference #:  P02489 (UniProtKB)
Alt. Names/Synonyms: Alpha-crystallin A chain; Alpha-crystallin A chain, short form; Alpha-crystallin A(1-162); Alpha-crystallin A(1-168); Alpha-crystallin A(1-172); CRYA1; CRYAA; crystallin alpha A; crystallin, alpha A; crystallin, alpha-1; CTRCT9; Heat shock protein beta-4; HSPB4; human alphaA-crystallin (CRYA1)
Gene Symbols: CRYAA
Molecular weight: 19,909 Da
Basal Isoelectric point: 5.77  Predict pI for various phosphorylation states
Select Structure to View Below

CRYA1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB