IL4R Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells. Belongs to the type I cytokine receptor family. Type 4 subfamily. Isoform 1 and isoform 2 are highly expressed in activated T-cells. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of mouse Ortholog: 7 F3|7 68.94 cM
Cellular Component:  extracellular region; extracellular space; integral component of membrane; membrane; plasma membrane; receptor complex
Molecular Function:  cytokine receptor activity; protein binding
Biological Process:  defense response to protozoan; immune system process; immunoglobulin mediated immune response; negative regulation of T-helper 1 cell differentiation; positive regulation of chemokine secretion; positive regulation of cold-induced thermogenesis; positive regulation of immunoglobulin production; positive regulation of macrophage activation; positive regulation of mast cell degranulation; positive regulation of myoblast fusion; positive regulation of T-helper 2 cell differentiation; production of molecular mediator involved in inflammatory response; regulation of cell proliferation
Reference #:  P16382 (UniProtKB)
Alt. Names/Synonyms: CD124; IL-4 receptor alpha chain; IL-4 receptor subunit alpha; IL-4-binding protein; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; IL4-BP; Il4r; Il4ra; interleukin 4 receptor, alpha; Interleukin-4 receptor subunit alpha; MGC118473; sIL4Ralpha/prot; Soluble IL-4 receptor subunit alpha; Soluble IL-4R-alpha; Soluble interleukin-4 receptor subunit alpha
Gene Symbols: Il4r
Molecular weight: 87,627 Da
Basal Isoelectric point: 4.97  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene