|
MZF-1
Binds to target promoter DNA and functions as transcription regulator. Regulates transcription from the PADI1 and CDH2 promoter. May be one regulator of transcriptional events during hemopoietic development. Belongs to the krueppel C2H2-type zinc-finger protein family. Preferentially expressed in differentiating myeloid cells. Detected in osteoblasts. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: C2H2-type zinc finger protein; DNA-binding; Transcription factor |
| Chromosomal Location of human Ortholog: 19q13.43 |
|
Cellular Component:
nucleoplasm
|
|
Molecular Function:
DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; metal ion binding; protein binding; protein homodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; transcription cis-regulatory region binding
|
|
Biological Process:
negative regulation of transcription by RNA polymerase II; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription
|
|
Reference #:
P28698
(UniProtKB)
|
|
Alt. Names/Synonyms: Myeloid zinc finger 1; MZF; MZF-1; MZF1; MZF1B; Zfp98; Zinc finger and SCAN domain-containing protein 6; Zinc finger protein 42; zinc finger protein 42 (myeloid-specific retinoic acid-responsive); ZNF42; ZSCAN6
|
|
Gene Symbols: MZF1
|
|
Molecular weight:
82,055 Da
|
|
Basal Isoelectric point:
8.59
Predict pI for various phosphorylation states
|
