CCNE2 Essential for the control of the cell cycle at the late G1 and early S phase. Belongs to the cyclin family. Cyclin E subfamily. According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor-derived cells compared to non-transformed proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. According to PubMed:9840943 highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Activator; Cell cycle regulation
Chromosomal Location of Human Ortholog: 4|4 A1
Cellular Component:  centrosome; cyclin E1-CDK2 complex; cyclin E2-CDK2 complex; cyclin-dependent protein kinase holoenzyme complex; cytoplasm; nucleus
Molecular Function:  cyclin-dependent protein serine/threonine kinase regulator activity; protein kinase binding
Biological Process:  cell cycle; cell division; chromosome organization involved in meiotic cell cycle; DNA replication initiation; G1/S transition of mitotic cell cycle; mitotic cell cycle phase transition; regulation of cell cycle; regulation of cellular protein localization; regulation of cyclin-dependent protein serine/threonine kinase activity; synapsis; telomere maintenance
Reference #:  Q9Z238 (UniProtKB)
Alt. Names/Synonyms: Ccne2; cyclin E2; Cyclin-E2; G1/S-specific cyclin-E2; OTTMUSP00000004878; OTTMUSP00000004879
Gene Symbols: Ccne2
Molecular weight: 46,669 Da
Basal Isoelectric point: 7.95  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CCNE2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene