|
CCNE2
Essential for the control of the cell cycle at the late G1 and early S phase. Belongs to the cyclin family. Cyclin E subfamily. According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor-derived cells compared to non-transformed proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. According to PubMed:9840943 highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Activator; Cell cycle regulation |
| Chromosomal Location of mouse Ortholog: 4|4 A1 |
|
Cellular Component:
centrosome; cyclin E1-CDK2 complex; cyclin E2-CDK2 complex; cytoplasm; nucleus
|
|
Molecular Function:
cyclin-dependent protein serine/threonine kinase regulator activity; protein kinase binding
|
|
Biological Process:
cell cycle; cell division; chromosome organization involved in meiotic cell cycle; DNA replication initiation; G1/S transition of mitotic cell cycle; homologous chromosome pairing at meiosis; regulation of cell cycle; regulation of cyclin-dependent protein serine/threonine kinase activity; regulation of protein localization; telomere maintenance
|
|
Reference #:
Q9Z238
(UniProtKB)
|
|
Alt. Names/Synonyms: Ccne2; cyclin E2; Cyclin-E2; G1/S-specific cyclin-E2; OTTMUSP00000004878; OTTMUSP00000004879
|
|
Gene Symbols: Ccne2
|
|
Molecular weight:
46,669 Da
|
|
Basal Isoelectric point:
7.95
Predict pI for various phosphorylation states
|
|
CST Pathways:
G1/S Checkpoint
|
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
|
