CCNE2 Essential for the control of the cell cycle at the late G1 and early S phase. Belongs to the cyclin family. Cyclin E subfamily. According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor-derived cells compared to non-transformed proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. According to PubMed:9840943 highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Activator; Cell cycle regulation
Chromosomal Location of Human Ortholog: 8q22.1
Cellular Component:  cyclin E2-CDK2 complex; cytosol; nucleoplasm
Molecular Function:  protein binding
Biological Process:  cell division; DNA replication initiation; G1/S transition of mitotic cell cycle; protein phosphorylation; regulation of cellular protein localization; telomere maintenance
Reference #:  O96020 (UniProtKB)
Alt. Names/Synonyms: CCNE2; CYCE2; cyclin E2; Cyclin-E2; G1/S-specific cyclin E2; G1/S-specific cyclin-E2
Gene Symbols: CCNE2
Molecular weight: 46,757 Da
Basal Isoelectric point: 7.95  Predict pI for various phosphorylation states
CST Pathways:  G1/S Checkpoint
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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