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MMP9
May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly-|-Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide. Belongs to the peptidase M10A family. Detected in neutrophils (at protein level) (PubMed:7683678). Produced by normal alveolar macrophages and granulocytes. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.4.24.35; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide |
| Chromosomal Location of Human Ortholog: 2 H3|2 85.27 cM |
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Cellular Component:
extracellular matrix; extracellular region; extracellular space; protein-containing complex
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Molecular Function:
endopeptidase activity; fibronectin binding; hydrolase activity; identical protein binding; metal ion binding; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protein-containing complex binding; serine-type endopeptidase activity; zinc ion binding
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Biological Process:
aging; cellular response to cadmium ion; cellular response to cell-matrix adhesion; cellular response to reactive oxygen species; collagen catabolic process; embryo implantation; extracellular matrix organization; heart development; leukocyte migration; negative regulation of apoptotic process; negative regulation of cation channel activity; negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway; negative regulation of epithelial cell differentiation involved in kidney development; negative regulation of fibroblast proliferation; negative regulation of intrinsic apoptotic signaling pathway; ossification; positive regulation of angiogenesis; positive regulation of apoptotic process; positive regulation of cell migration; positive regulation of DNA binding; positive regulation of epidermal growth factor receptor signaling pathway; positive regulation of keratinocyte migration; positive regulation of leukocyte migration; positive regulation of protein phosphorylation; positive regulation of receptor binding; positive regulation of release of cytochrome c from mitochondria; positive regulation of synaptic plasticity; positive regulation of vascular smooth muscle cell proliferation; protein complex oligomerization; proteolysis; response to amyloid-beta; response to drug; response to oxidative stress; skeletal system development; tissue remodeling; transformation of host cell by virus
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Reference #:
P41245
(UniProtKB)
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Alt. Names/Synonyms: 92 kDa gelatinase; 92 kDa type IV collagenase; 92kD gelatinase; 92kD type IV collagenase; 92kDa gelatinase; 92kDa type IV collagenase; AW743869; B/MMP; B/MMP9; Clg4; Clg4b; collagenase type IVB; Gel B; Gelatinase B; GELB; matrix metallopeptidase 9; matrix metalloproteinase 9; Matrix metalloproteinase-9; MMP-; MMP-9; Mmp9; OTTMUSP00000001145; pro-MMP-9
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Gene Symbols: Mmp9
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Molecular weight:
80,535 Da
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Basal Isoelectric point:
5.7
Predict pI for various phosphorylation states
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CST Pathways:
Angiogenesis
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GPCR Signaling to MAPKs
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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