|
DNCLI1
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. Belongs to the dynein light intermediate chain family. Note: This description may include information from UniProtKB.
|
| Protein type: Cell cycle regulation; Cytoskeletal; Microtubule-binding; Motility/polarity/chemotaxis; Motor |
| Chromosomal Location of mouse Ortholog: 9|9 F3 |
|
Cellular Component:
centrosome; chromosome; chromosome, centromeric region; cytoplasm; cytoplasmic dynein complex; cytoskeleton; dynein complex; kinetochore; late endosome; microtubule; spindle pole
|
|
Molecular Function:
ATP binding; dynein heavy chain binding; GDP binding; identical protein binding; microtubule motor activity; molecular adaptor activity; nucleotide binding
|
|
Biological Process:
cell cycle; cell division; cellular response to nerve growth factor stimulus; microtubule cytoskeleton organization; microtubule-based movement; positive regulation of mitotic cell cycle spindle assembly checkpoint; regulation of centrosome cycle
|
|
Reference #:
Q8R1Q8
(UniProtKB)
|
|
Alt. Names/Synonyms: 1110053F02Rik; Cytoplasmic dynein 1 light intermediate chain 1; DC1L1; DLC-A; Dncl; Dncli1; Dnclic1; Dync1li1; dynein cytoplasmic 1 light intermediate chain 1; Dynein light chain A; Dynein light intermediate chain 1, cytosolic; dynein, cytoplasmic, light intermediate chain 1; LIC; LIC-1; MGC32416
|
|
Gene Symbols: Dync1li1
|
|
Molecular weight:
56,614 Da
|
|
Basal Isoelectric point:
6.01
Predict pI for various phosphorylation states
|
