DNCLI1 Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores. Belongs to the dynein light intermediate chain family. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; Cytoskeletal; Microtubule-binding; Motility/polarity/chemotaxis; Motor
Chromosomal Location of Human Ortholog: 9|9 F3
Cellular Component:  centrosome; chromosome; chromosome, centromeric region; cytoplasm; cytoplasmic dynein complex; cytoskeleton; dynein complex; kinetochore; microtubule; spindle pole
Molecular Function:  ATP binding; dynein heavy chain binding; GDP binding; microtubule motor activity; motor activity; nucleotide binding
Biological Process:  cell cycle; cell division; cellular response to nerve growth factor stimulus; microtubule cytoskeleton organization; microtubule-based movement; positive regulation of mitotic cell cycle spindle assembly checkpoint; protein homooligomerization; regulation of centrosome cycle
Reference #:  Q8R1Q8 (UniProtKB)
Alt. Names/Synonyms: 1110053F02Rik; Cytoplasmic dynein 1 light intermediate chain 1; DC1L1; DLC-A; Dncl; Dncli1; Dnclic1; Dync1li1; dynein cytoplasmic 1 light intermediate chain 1; Dynein light chain A; Dynein light intermediate chain 1, cytosolic; dynein, cytoplasmic, light intermediate chain 1; LIC; LIC-1; MGC32416
Gene Symbols: Dync1li1
Molecular weight: 56,614 Da
Basal Isoelectric point: 6.01  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene