ADCY3 a membrane-associated enzyme that catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Involved in odorant detection (possibly) via modulation of intracellular cAMP concentration. Note: This description may include information from UniProtKB.
Protein type: Adenylyl cyclase; EC; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family
Chromosomal Location of Human Ortholog: 2p23.3
Cellular Component:  cilium; cytoplasm; Golgi apparatus; integral component of membrane; plasma membrane
Molecular Function:  adenylate cyclase activity; ATP binding; calmodulin binding; metal ion binding
Biological Process:  acrosome reaction; activation of adenylate cyclase activity; activation of protein kinase A activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; cAMP biosynthetic process; cellular response to forskolin; cellular response to glucagon stimulus; flagellated sperm motility; G protein-coupled receptor signaling pathway; olfactory learning; renal water homeostasis; sensory perception of smell; signal transduction; single fertilization
Disease: Body Mass Index Quantitative Trait Locus 19
Reference #:  O60266 (UniProtKB)
Alt. Names/Synonyms: AC-III; AC3; ADCY3; adenylate cyclase 3; Adenylate cyclase type 3; Adenylate cyclase type III; Adenylate cyclase, olfactive type; Adenylyl cyclase 3; adenylyl cyclase, type III; ATP pyrophosphate-lyase 3; KIAA0511
Gene Symbols: ADCY3
Molecular weight: 128,960 Da
Basal Isoelectric point: 6.15  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  NF-kB Signaling  |  Parkinson's Disease
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene