ADCY3 Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level) (PubMed:11549699). Expressed in brain, heart, kidney, liver, lung, pancreas islets, placenta, and skeletal muscle (PubMed:9920776). Detected in testis (PubMed:15705663). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adenylyl cyclase; EC; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family
Chromosomal Location of human Ortholog: 2p23.3
Cellular Component:  ciliary membrane; cilium; cytoplasm; Golgi apparatus; membrane; plasma membrane
Molecular Function:  adenylate cyclase activity; ATP binding; calmodulin binding; metal ion binding
Biological Process:  acrosome reaction; adenylate cyclase-activating G protein-coupled receptor signaling pathway; cAMP biosynthetic process; cellular response to forskolin; flagellated sperm motility; intracellular signal transduction; olfactory learning; sensory perception of smell; signal transduction; single fertilization
Disease: Body Mass Index Quantitative Trait Locus 19
Reference #:  O60266 (UniProtKB)
Alt. Names/Synonyms: AC-III; AC3; ADCY3; adenylate cyclase 3; Adenylate cyclase type 3; Adenylate cyclase type III; Adenylate cyclase, olfactive type; Adenylyl cyclase 3; adenylyl cyclase, type III; ATP pyrophosphate-lyase 3; BMIQ19; KIAA0511
Gene Symbols: ADCY3
Molecular weight: 128,960 Da
Basal Isoelectric point: 6.15  Predict pI for various phosphorylation states
CST Pathways:  GPCR Signaling to MAPKs  |  NF-kB Signaling  |  Parkinson's Disease
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene