Claudin-4 Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Belongs to the claudin family. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 5 G2|5 74.9 cM
Cellular Component:  apical plasma membrane; apicolateral plasma membrane; basal plasma membrane; bicellular tight junction; cell junction; chloride channel complex; integral component of membrane; integral component of plasma membrane; lateral plasma membrane; membrane; plasma membrane
Molecular Function:  chloride channel activity; protein binding; structural molecule activity
Biological Process:  chloride transport; establishment of skin barrier; ion transport; renal absorption
Reference #:  O35054 (UniProtKB)
Alt. Names/Synonyms: Cep-r; claudin 4; Claudin-4; claudin4; CLD4; Cldn4; Clostridium perfringens enterotoxin receptor; CPE-R; CPE-receptor; Cper; Cpetr; Cpetr1
Gene Symbols: Cldn4
Molecular weight: 22,339 Da
Basal Isoelectric point: 8.65  Predict pI for various phosphorylation states
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Claudin-4

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene