acinus iso4 Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. Ubiquitous. The Ser-1180 phosphorylated form (by SRPK2) is highly expressed and phosphorylated in patients with myeloid hematologic malignancies. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; RNA splicing; RNA-binding; Spliceosome
Cellular Component:  ASAP complex; cytosol; nuclear speck; nucleolus; nucleoplasm; nucleus; plasma membrane
Molecular Function:  nucleic acid binding
Biological Process:  apoptotic chromosome condensation; apoptotic process; mRNA processing; negative regulation of mRNA splicing, via spliceosome; positive regulation of apoptotic process; RNA splicing
Reference #:  Q9JIX8-4 (UniProtKB)
Alt. Names/Synonyms: Acin1; acinus; acinus iso4
Gene Symbols: Acin1
Molecular weight: 146,302 Da
Basal Isoelectric point: 5.86  Predict pI for various phosphorylation states
CST Pathways:  Death Receptor Signaling
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acinus iso4

Protein Structure Not Found.


Cross-references to other databases:  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene