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ACTN1
F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Belongs to the alpha-actinin family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of Human Ortholog: 12 C3|12 36.49 cM |
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Cellular Component:
brush border; cell junction; cell projection; cell-cell junction; cortical cytoskeleton; cytoplasm; cytoskeleton; dendritic spine; dense core granule membrane; fascia adherens; focal adhesion; glutamatergic synapse; membrane; nucleus; plasma membrane; ruffle; sarcomere; secretory granule; stress fiber; Z disc
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Molecular Function:
actin binding; actin filament binding; calcium ion binding; double-stranded RNA binding; integrin binding; ion channel binding; metal ion binding; nuclear receptor transcription coactivator activity; protein binding; protein domain specific binding; protein homodimerization activity; structural constituent of postsynapse; vinculin binding
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Biological Process:
actin crosslink formation; actin filament bundle assembly; actin filament network formation; actin filament organization; cortical cytoskeleton organization; focal adhesion assembly; negative regulation of cellular component movement; platelet formation; platelet morphogenesis; postsynapse organization; synapse organization
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Reference #:
Q7TPR4
(UniProtKB)
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Alt. Names/Synonyms: 3110023F10Rik; actinin, alpha 1; Actn1; Actn1a; alpha actinin 1a; Alpha-actinin cytoskeletal isoform; Alpha-actinin-1; F-actin cross-linking protein; Non-muscle alpha-actinin-1
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Gene Symbols: Actn1
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Molecular weight:
103,068 Da
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Basal Isoelectric point:
5.23
Predict pI for various phosphorylation states
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CST Pathways:
T Cell Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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