NFAT5 Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Mediates the transcriptional response to hypertonicity. Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3'. Widely expressed, with highest levels in skeletal muscle, brain, heart and peripheral blood leukocytes. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription factor
Chromosomal Location of mouse Ortholog: 8 D3|8 53.93 cM
Cellular Component:  chromosome; cytoplasm; cytosol; nucleoplasm; nucleus; transcription regulator complex
Molecular Function:  chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding; transcription factor binding
Biological Process:  calcineurin-NFAT signaling cascade; cellular response to cytokine stimulus; cytokine production; DNA damage response; DNA-templated transcription; negative regulation of urine volume; positive regulation of gene expression; positive regulation of leukocyte adhesion to vascular endothelial cell; positive regulation of NIK/NF-kappaB signaling; positive regulation of transcription by RNA polymerase II; R-loop processing; regulation of calcineurin-NFAT signaling cascade; regulation of DNA-templated transcription; regulation of transcription by RNA polymerase II; renal water homeostasis; response to water deprivation
Reference #:  Q9WV30 (UniProtKB)
Alt. Names/Synonyms: AI225870; B130038B15Rik; CAG-8; CAG80; mKIAA0827; NF-AT5; nfa; Nfat5; NFATL1; nfatz; nuclear factor of activated T cells 5; Nuclear factor of activated T-cells 5; OREBP; Rel domain-containing transcription factor NFAT5; T-cell transcription factor NFAT5; Ton; TonEBP; tonicity-responsive enhancer binding protein
Gene Symbols: Nfat5
Molecular weight: 165,800 Da
Basal Isoelectric point: 5.07  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  T Cell Receptor Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene