Tho1 Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Regulates transcriptional elongation of a subset of genes. Involved in genome stability by preventing co-transcriptional R-loop formation. Participates in an apoptotic pathway which is characterized by activation of caspase-6, increases in the expression of BAK1 and BCL2L1 and activation of NF-kappa-B. This pathway does not require p53/TP53, nor does the presence of p53/TP53 affect the efficiency of cell killing. Activates a G2/M cell cycle checkpoint prior to the onset of apoptosis. Apoptosis is inhibited by association with RB1. Ubiquitous. Expressed in various cancer cell lines. Expressed at very low levels in normal breast epithelial cells and highly expressed in breast tumors. Expression is strongly associated with an aggressive phenotype of breast tumors and expression correlates with tumor size and the metastatic state of the tumor progression. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Spliceosome
Chromosomal Location of mouse Ortholog: 18|18 A1
Cellular Component:  chromosome, telomeric region; cytoplasm; nuclear speck; nucleus; THO complex; THO complex part of transcription export complex; transcription export complex
Molecular Function:  DNA binding; protein binding; RNA binding
Biological Process:  apoptotic process; mRNA export from nucleus; mRNA processing; mRNA transport; negative regulation of DNA damage checkpoint; negative regulation of isotype switching to IgA isotypes; positive regulation of DNA-templated transcription, elongation; regulation of apoptotic process; regulation of DNA recombination; regulation of DNA-templated transcription elongation; replication fork processing; RNA splicing; signal transduction; viral mRNA export from host cell nucleus
Reference #:  Q8R3N6 (UniProtKB)
Alt. Names/Synonyms: 3110002N20Rik; AW107452; Hpr1; MGC28284; NMP-; NMP-84; Nuclear matrix protein p84; THO complex 1; THO complex subunit 1; Tho1; Thoc1
Gene Symbols: Thoc1
Molecular weight: 75,436 Da
Basal Isoelectric point: 4.89  Predict pI for various phosphorylation states
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Tho1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein