TP1 Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction. Belongs to the nuclear transition protein 1 family. Expressed by spermatids (at protein level). Note: This description may include information from UniProtKB.
Protein type: DNA-binding
Chromosomal Location of rat Ortholog: 9q33
Cellular Component:  male germ cell nucleus; nucleosome; nucleus
Molecular Function:  DNA binding
Biological Process:  chromatin remodeling; flagellated sperm motility; heterochromatin formation; negative regulation of DNA-templated transcription; nucleosome disassembly; positive regulation of protein processing; sexual reproduction; single strand break repair; sperm DNA condensation; spermatid development; spermatid nucleus elongation; spermatogenesis
Reference #:  P02317 (UniProtKB)
Alt. Names/Synonyms: Spermatid nuclear transition protein 1; STP-1; Testis-specific basic protein; Tnp1; TP-1; TP1; transition protein 1
Gene Symbols: Tnp1
Molecular weight: 6,395 Da
Basal Isoelectric point: 12.09  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene