TNIK Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. Expressed ubiquitously. Highest levels observed in heart, brain and skeletal muscle. Expressed in normal colonic epithelia and colorectal cancer tissues. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; MSN subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family
Chromosomal Location of Human Ortholog: 3|3 A3
Cellular Component:  apical plasma membrane; cytoplasm; cytoskeleton; cytosol; endosome; glutamatergic synapse; nucleoplasm; nucleus; perinuclear region of cytoplasm; recycling endosome
Molecular Function:  ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  actin cytoskeleton reorganization; activation of JNKK activity; activation of protein kinase activity; cytoskeleton organization; intracellular signal transduction; MAPK cascade; microvillus assembly; nervous system development; neuron projection morphogenesis; phosphorylation; positive regulation of protein phosphorylation; protein autophosphorylation; protein localization to plasma membrane; protein phosphorylation; regulation of dendrite morphogenesis; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; signal transduction by protein phosphorylation; stress-activated protein kinase signaling cascade; Wnt signaling pathway
Reference #:  P83510 (UniProtKB)
Alt. Names/Synonyms: 1500031A17Rik; 4831440I19Rik; AI451411; C530008O15Rik; C630040K21Rik; Kiaa0551; MGC189819; MGC189859; Tnik; TRAF2 and NCK interacting kinase; Traf2 and NCK-interacting protein kinase; ZC2
Gene Symbols: Tnik
Molecular weight: 150,367 Da
Basal Isoelectric point: 6.82  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein