RPT3
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. Belongs to the AAA ATPase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Nuclear receptor co-regulator; Protease; Proteasome complex |
Chromosomal Location of mouse Ortholog: 7 A3|7 16.11 cM |
Cellular Component:
cytoplasm; cytosol; cytosolic proteasome complex; inclusion body; nucleoplasm; nucleus; proteasome accessory complex; proteasome complex; proteasome regulatory particle, base subcomplex; synapse
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Molecular Function:
ATP binding; ATP hydrolysis activity; nucleotide binding; proteasome-activating activity
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Biological Process:
blastocyst development; proteasome-mediated ubiquitin-dependent protein catabolic process; protein catabolic process
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Reference #:
P54775
(UniProtKB)
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Alt. Names/Synonyms: 26S protease regulatory subunit 6B; 26S proteasome AAA-ATPase subunit RPT3; 26S proteasome regulatory subunit 6B; CAR interacing protein 21; CAR interacting protein 21; CIP; CIP21; MB67-interacting protein; MGC103150; MIP2; MIP224; OTTMUSP00000030278; proteasome (prosome, macropain) 26S subunit, ATPase, 4; proteasome 26S ATPase subunit 4; Proteasome 26S subunit ATPase 4; PRS6B; Psmc4; RPT3; Tat-binding protein 7; TBP-7; Tbp7
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Gene Symbols: Psmc4
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Molecular weight:
47,408 Da
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Basal Isoelectric point:
5.09
Predict pI for various phosphorylation states
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