PTHR Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 2 family. Expressed in most tissues. Most abundant in kidney, bone and liver. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component:  apical plasma membrane; basolateral plasma membrane; brush border membrane; cytoplasm; integral component of plasma membrane; nucleus; plasma membrane; receptor complex
Molecular Function:  parathyroid hormone receptor activity; peptide hormone binding; protein binding; protein homodimerization activity; protein self-association
Biological Process:  adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; aging; bone mineralization; bone resorption; cell maturation; cell surface receptor signaling pathway; chondrocyte differentiation; G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; negative regulation of cell proliferation; osteoblast development; phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of cell proliferation; positive regulation of cytosolic calcium ion concentration; positive regulation of inositol phosphate biosynthetic process; skeletal system development
Disease: Chondrodysplasia, Blomstrand Type; Eiken Syndrome; Failure Of Tooth Eruption, Primary; Metaphyseal Chondrodysplasia, Jansen Type
Reference #:  Q03431 (UniProtKB)
Alt. Names/Synonyms: EKNS; MGC138426; MGC138452; Parathyroid hormone 1 receptor; parathyroid hormone receptor 1; Parathyroid hormone/parathyroid hormone-related peptide receptor; parathyroid hormone/parathyroid hormone-related protein receptor; PFE; PTH/PTHr receptor; PTH/PTHrP type I receptor; PTH1 receptor; PTH1R; PTHR; PTHR1; seven transmembrane helix receptor
Gene Symbols: PTH1R
Molecular weight: 66,361 Da
Basal Isoelectric point: 8.25  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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