SF3B4 Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex. SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. Belongs to the SF3B4 family. Note: This description may include information from UniProtKB.
Protein type: RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 3|3 F2.1
Cellular Component:  nucleolus; nucleus; ribonucleoprotein complex; spliceosomal complex; U12-type spliceosomal complex; U2-type precatalytic spliceosome
Molecular Function:  nucleic acid binding; RNA binding
Biological Process:  mRNA processing; mRNA splicing, via spliceosome; positive regulation of mRNA splicing, via spliceosome; RNA splicing
Reference #:  Q8QZY9 (UniProtKB)
Alt. Names/Synonyms: 49kD; 49kDa; MGC36369; MGC36564; OTTMUSP00000024556; Sap49; Sf3b4; SF3b49; SF3b50; spliceosome associated protein 49; Splicing factor 3B subunit 4; splicing factor 3b, subunit 4; splicing factor 3b, subunit 4, 49kD
Gene Symbols: Sf3b4
Molecular weight: 44,356 Da
Basal Isoelectric point: 8.55  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene