SF3A1 Involved in pre-mRNA splicing as a component of the splicing factor SF3A complex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes. Ubiquitously expressed. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of mouse Ortholog: 11|11 A1
Cellular Component:  catalytic step 2 spliceosome; nuclear speck; nucleoplasm; nucleus; spliceosomal complex; U2 snRNP; U2-type precatalytic spliceosome; U2-type prespliceosome; U2-type spliceosomal complex
Molecular Function:  RNA binding
Biological Process:  mRNA cis splicing, via spliceosome; mRNA processing; mRNA splicing, via spliceosome; RNA processing; RNA splicing; U2-type prespliceosome assembly
Reference #:  Q8K4Z5 (UniProtKB)
Alt. Names/Synonyms: 1200014H24Rik; 5930416L09Rik; AI159724; OTTMUSP00000005252; Sf3a1; SF3a120; splicing factor 3 subunit 1; Splicing factor 3A subunit 1; splicing factor 3a, subunit 1
Gene Symbols: Sf3a1
Molecular weight: 88,545 Da
Basal Isoelectric point: 5.15  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein