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ARHGAP12
GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GAP; GAP, Rac/Rho |
| Chromosomal Location of mouse Ortholog: 18|18 A1 |
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Cellular Component:
cytoplasm; phagocytic cup
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Molecular Function:
GTPase activator activity
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Biological Process:
actin filament organization; morphogenesis of an epithelial sheet; negative regulation of small GTPase mediated signal transduction; phagocytosis, engulfment; regulation of GTPase activity; signal transduction
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Reference #:
Q8C0D4
(UniProtKB)
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Alt. Names/Synonyms: 2810011M08Rik; Arhgap12; RHG12; Rho GTPase activating protein 12; Rho GTPase-activating protein 12; Rho-type GTPase-activating protein 12
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Gene Symbols: Arhgap12
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Molecular weight:
95,352 Da
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Basal Isoelectric point:
7.29
Predict pI for various phosphorylation states
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