PPAT Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. In the central section; belongs to the eukaryotic CoaD family. Expressed in all tissues examined including brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocyte. Lowest expression in peripheral blood leukocytes and highest in kidney and liver. Isoform 2 is expressed mainly in the brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; EC; EC; Kinase, other; Transferase
Chromosomal Location of Human Ortholog: 11|11 D
Cellular Component:  cytoplasm; cytosol; mitochondrial matrix; mitochondrion; nucleoplasm
Molecular Function:  ATP binding; catalytic activity; dephospho-CoA kinase activity; kinase activity; nucleotide binding; nucleotidyltransferase activity; pantetheine-phosphate adenylyltransferase activity; transferase activity
Biological Process:  biosynthetic process; coenzyme A biosynthetic process; metabolic process; phosphorylation
Reference #:  Q9DBL7 (UniProtKB)
Alt. Names/Synonyms: 1300003G02Rik; 4'-phosphopantetheine adenylyltransferase and dephospho-CoA kinase; Bifunctional coenzyme A synthase; CoA synthase; Coasy; Coenzyme A synthase; Dephospho-CoA kinase; Dephospho-CoA pyrophosphorylase; Dephosphocoenzyme A kinase; Dpc; DPCK; DPCOAK; OTTMUSP00000002516; Pantetheine-phosphate adenylyltransferase; Phosphopantetheine adenylyltransferase; PPAT; Ukr; Ukr1
Gene Symbols: Coasy
Molecular weight: 62,023 Da
Basal Isoelectric point: 6.61  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene