|
PABP 4
Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Belongs to the polyadenylate-binding protein type-1 family. Expressed at low levels in resting normal T cells; following T-cell activation, however, mRNA levels are rapidly up-regulated. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: RNA-binding; Translation |
| Chromosomal Location of mouse Ortholog: 4|4 D2.2 |
|
Cellular Component:
cytoplasm; cytoplasmic stress granule; cytosol; nucleus; ribonucleoprotein complex
|
|
Molecular Function:
mRNA 3'-UTR binding; mRNA binding; poly(A) binding; poly(C) RNA binding; poly(U) RNA binding
|
|
Biological Process:
myeloid cell development; regulation of mRNA stability
|
|
Reference #:
Q6PHQ9
(UniProtKB)
|
|
Alt. Names/Synonyms: MCG5546, isoform CRA_c; MGC11665; MGC6685; OTTMUSP00000009342; OTTMUSP00000009343; PABP; PABP 4; Pabpc4; Poly A binding protein, cytoplasmic 4; Poly(A) binding protein, cytoplasmic 4; Polyadenylate-binding protein; polyadenylate-binding protein 4
|
|
Gene Symbols: Pabpc4
|
|
Molecular weight:
72,242 Da
|
|
Basal Isoelectric point:
9.43
Predict pI for various phosphorylation states
|
