P2X7 Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells. Belongs to the P2X receptor family. Widely expressed with highest levels in brain and immune tissues. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.
Chromosomal Location of Human Ortholog: 5|5 F
Cellular Component:  cell-cell junction; external side of plasma membrane; integral component of membrane; integral component of nuclear inner membrane; integral component of plasma membrane; membrane; neuromuscular junction; neuronal cell body; plasma membrane; synapse
Molecular Function:  ATP binding; ATP-gated ion channel activity; channel activity; extracellularly ATP-gated cation channel activity; ion channel activity; lipopolysaccharide binding; protein binding; purinergic nucleotide receptor activity; signaling receptor activity
Biological Process:  activation of MAPK activity; bleb assembly; calcium ion transport; cation transmembrane transport; cation transport; cell death; cell morphogenesis; cell volume homeostasis; cellular response to dsRNA; cellular response to extracellular stimulus; cellular response to organic cyclic compound; ceramide biosynthetic process; collagen metabolic process; defense response to Gram-positive bacterium; extrinsic apoptotic signaling pathway; gene expression; homeostasis of number of cells within a tissue; inflammatory response; ion transmembrane transport; ion transport; membrane depolarization; membrane protein ectodomain proteolysis; mitochondrion organization; NAD transport; negative regulation of bone resorption; negative regulation of cell volume; negative regulation of MAPK cascade; phagolysosome assembly; phospholipid scrambling; phospholipid transfer to membrane; phospholipid translocation; plasma membrane organization; pore complex assembly; positive regulation of apoptotic process; positive regulation of bleb assembly; positive regulation of bone mineralization; positive regulation of calcium ion transport into cytosol; positive regulation of catalytic activity; positive regulation of cytokine secretion; positive regulation of gamma-aminobutyric acid secretion; positive regulation of gene expression; positive regulation of glutamate secretion; positive regulation of glycolytic process; positive regulation of interleukin-1 alpha secretion; positive regulation of interleukin-1 beta production; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-6 production; positive regulation of ion transmembrane transport; positive regulation of lymphocyte apoptotic process; positive regulation of MAPK cascade; positive regulation of mitochondrial depolarization; positive regulation of ossification; positive regulation of prostaglandin secretion; positive regulation of protein phosphorylation; positive regulation of protein secretion; positive regulation of T cell mediated cytotoxicity; programmed cell death; protein catabolic process; protein complex oligomerization; protein phosphorylation; protein processing; purinergic nucleotide receptor signaling pathway; reactive oxygen species metabolic process; release of sequestered calcium ion into cytosol; response to ATP; response to bacterium; response to calcium ion; response to drug; response to electrical stimulus; response to fluid shear stress; response to lipopolysaccharide; response to mechanical stimulus; response to organic cyclic compound; response to organic substance; response to zinc ion; sensory perception of pain; skeletal system morphogenesis; synaptic vesicle exocytosis; T cell homeostasis; T cell proliferation; vesicle budding from membrane
Reference #:  Q9Z1M0 (UniProtKB)
Alt. Names/Synonyms: AI467586; ATP receptor; P2rx7; P2X; P2X purinoceptor; P2X purinoceptor 7; P2X(7; P2X(7); P2X7; P2X7 purinoceptor; P2X7 receptor; P2X7R; P2Z receptor; Purinergic receptor; purinergic receptor P2X, ligand-gated ion channel, 7
Gene Symbols: P2rx7
Molecular weight: 68,388 Da
Basal Isoelectric point: 8.58  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene