P2X7 a receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis by macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Alternatively spliced variants encoding different isoforms have been identified. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. Phosphorylation results in its inactivation. Note: This description may include information from UniProtKB.
Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.
Chromosomal Location of Human Ortholog: 5|5 F
Cellular Component:  cell-cell junction; external side of plasma membrane; integral component of membrane; integral component of nuclear inner membrane; integral component of plasma membrane; membrane; neuromuscular junction; neuronal cell body; plasma membrane; synapse
Molecular Function:  ATP binding; ATP-gated ion channel activity; channel activity; extracellularly ATP-gated cation channel activity; ion channel activity; lipopolysaccharide binding; protein binding; purinergic nucleotide receptor activity; signaling receptor activity
Biological Process:  activation of MAPK activity; bleb assembly; calcium ion transport; cation transmembrane transport; cation transport; cell death; cell morphogenesis; cell volume homeostasis; cellular response to dsRNA; cellular response to extracellular stimulus; cellular response to organic cyclic compound; ceramide biosynthetic process; collagen metabolic process; defense response to Gram-positive bacterium; extrinsic apoptotic signaling pathway; gene expression; homeostasis of number of cells within a tissue; inflammatory response; ion transmembrane transport; ion transport; membrane depolarization; membrane protein ectodomain proteolysis; mitochondrion organization; NAD transport; negative regulation of bone resorption; negative regulation of cell volume; negative regulation of MAPK cascade; phagolysosome assembly; phospholipid scrambling; phospholipid transfer to membrane; phospholipid translocation; plasma membrane organization; pore complex assembly; positive regulation of apoptotic process; positive regulation of bleb assembly; positive regulation of bone mineralization; positive regulation of calcium ion transport into cytosol; positive regulation of catalytic activity; positive regulation of cytokine secretion; positive regulation of gamma-aminobutyric acid secretion; positive regulation of gene expression; positive regulation of glutamate secretion; positive regulation of glycolytic process; positive regulation of interleukin-1 alpha secretion; positive regulation of interleukin-1 beta production; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-6 production; positive regulation of ion transmembrane transport; positive regulation of lymphocyte apoptotic process; positive regulation of MAPK cascade; positive regulation of mitochondrial depolarization; positive regulation of ossification; positive regulation of prostaglandin secretion; positive regulation of protein phosphorylation; positive regulation of protein secretion; positive regulation of T cell mediated cytotoxicity; programmed cell death; protein catabolic process; protein complex oligomerization; protein phosphorylation; protein processing; purinergic nucleotide receptor signaling pathway; reactive oxygen species metabolic process; release of sequestered calcium ion into cytosol; response to ATP; response to bacterium; response to calcium ion; response to drug; response to electrical stimulus; response to fluid shear stress; response to lipopolysaccharide; response to mechanical stimulus; response to organic cyclic compound; response to organic substance; response to zinc ion; sensory perception of pain; skeletal system morphogenesis; synaptic vesicle exocytosis; T cell homeostasis; T cell proliferation; vesicle budding from membrane
Reference #:  Q9Z1M0 (UniProtKB)
Alt. Names/Synonyms: AI467586; P2rx7; P2X purinoceptor; P2X purinoceptor 7; P2X(7); P2X7 purinoceptor; P2X7 receptor; P2X7R; P2Z receptor; purinergic receptor P2X, ligand-gated ion channel, 7
Gene Symbols: P2rx7
Molecular weight: 68,388 Da
Basal Isoelectric point: 8.58  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene