P2X2 Binding of this ligand-gated ion channel to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Belongs to the P2X receptor family. 7 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 5|5 F
Cellular Component:  apical plasma membrane; cell surface; dendritic spine; glutamatergic synapse; integral component of membrane; integral component of nuclear inner membrane; integral component of plasma membrane; integral component of presynaptic active zone membrane; membrane; neuronal cell body; plasma membrane; postsynaptic density; presynaptic membrane; receptor complex; terminal bouton
Molecular Function:  ATP binding; ATP-gated ion channel activity; cadmium ion binding; cobalt ion binding; copper ion binding; drug binding; extracellularly ATP-gated cation channel activity; identical protein binding; ion channel activity; ligand-gated ion channel activity; mercury ion binding; nickel cation binding; phosphatidylinositol binding; purinergic nucleotide receptor activity; zinc ion binding
Biological Process:  behavioral response to pain; cation transmembrane transport; cation transport; chemical synaptic transmission; detection of hypoxic conditions in blood by carotid body chemoreceptor signaling; ion transmembrane transport; ion transport; neuromuscular junction development; neuromuscular synaptic transmission; neuronal action potential; peristalsis; protein heterooligomerization; protein homooligomerization; regulation of presynaptic cytosolic calcium ion concentration; regulation of synaptic vesicle exocytosis; response to ATP; response to carbohydrate; response to hypoxia; response to ischemia; response to organic substance; sensory perception of sound; sensory perception of taste; skeletal muscle fiber development; urinary bladder smooth muscle contraction
Reference #:  Q8K3P1 (UniProtKB)
Alt. Names/Synonyms: MGC129148; MGC129149; P2rx2; P2X purinoceptor; P2X purinoceptor 2; P2x2; P2X2a; purinergic receptor P2X, ligand-gated ion channel, 2; purinergic receptor P2X2
Gene Symbols: P2rx2
Molecular weight: 53,937 Da
Basal Isoelectric point: 8.14  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene