PRDX1 Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation. Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 1.11.1.15; Nuclear receptor co-regulator; Oxidoreductase
Chromosomal Location of rat Ortholog: 5q35
Cellular Component:  cytoplasm; cytosol; mitochondrial matrix; nuclear euchromatin; nucleolus; nucleus; peroxisomal matrix
Molecular Function:  heme binding; identical protein binding; peroxidase activity; peroxiredoxin activity; protein homodimerization activity; thioredoxin peroxidase activity
Biological Process:  cell proliferation; cell redox homeostasis; erythrocyte homeostasis; hydrogen peroxide catabolic process; leukocyte activation; natural killer cell activation; natural killer cell mediated cytotoxicity; oxidation-reduction process; regulation of NIK/NF-kappaB signaling; regulation of stress-activated MAPK cascade; removal of superoxide radicals; response to oxidative stress; response to reactive oxygen species
Reference #:  Q63716 (UniProtKB)
Alt. Names/Synonyms: HBP23; Heme-binding 23 kDa protein; MGC108617; NKEF-A; peroxiredoxin 1; Peroxiredoxin-1; Prdx1; Tdpx2; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2
Gene Symbols: Prdx1
Molecular weight: 22,109 Da
Basal Isoelectric point: 8.27  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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PRDX1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA