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PRDX1
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation. Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. Note: This description may include information from UniProtKB.
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| Protein type: EC 1.11.1.15; Nuclear receptor co-regulator; Oxidoreductase |
| Chromosomal Location of rat Ortholog: 5q35 |
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Cellular Component:
cytoplasm; cytosol; euchromatin; mitochondrial matrix; nucleus; peroxisomal matrix
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Molecular Function:
heme binding; identical protein binding; peroxidase activity; peroxiredoxin activity; thioredoxin peroxidase activity
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Biological Process:
cell redox homeostasis; cellular response to stress; erythrocyte homeostasis; fibroblast proliferation; hydrogen peroxide catabolic process; leukocyte activation; natural killer cell activation; natural killer cell mediated cytotoxicity; regulation of NIK/NF-kappaB signaling; regulation of stress-activated MAPK cascade; removal of superoxide radicals; response to oxidative stress; response to reactive oxygen species; retina homeostasis
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Reference #:
Q63716
(UniProtKB)
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Alt. Names/Synonyms: HBP23; Heme-binding 23 kDa protein; MGC108617; NKEF-A; peroxiredoxin 1; Peroxiredoxin-1; Prdx1; Tdpx2; Thioredoxin peroxidase 2; Thioredoxin-dependent peroxide reductase 2
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Gene Symbols: Prdx1
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Molecular weight:
22,109 Da
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Basal Isoelectric point:
8.27
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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